The Asia-Pacific Journal of Ophthalmology

Asia-Pacific Journal of Ophthalmology:

Issue 1, January/February 2017 Original Study - Clinical

Prevalence of Steroid-Induced Cataract and Glaucoma in Chronic Obstructive Pulmonary Disease Patients Attending a Tertiary Care Center in India

Nath, Tirupati; Roy, Subham Sinha; Kumar, Himanshu; Agrawal, Rachit; Kumar, Santosh; Satsangi, S. K.



Author Information


From the *Upgraded Department of Ophthalmology and †Department of Tuberculosis and Chest Diseases, S. N. Medical College, Agra, India.

 

Reprints: Subham Sinha Roy, MBBS, Room No. 20, PG Boys Hostel, S. N. Medical College, Agra 282002, India. E-mail: subhamsinharoy@gmail.com.

 


Abstract


Purpose: Exposure to corticosteroids is known to be associated with an increased risk of cataract and glaucoma. this study was undertaken to determine the prevalence of steroid-induced cataract and glaucoma in patients with chronic obstructive pulmonary disease (COPD) and to assess a dose-response relationship between them.

 

Design: This was a prospective observational study.

 

Methods: We identified all COPD patients aged 50 years or older, with minimum steroid exposure of 4 months and on inhaled corticosteroids from March 2014 to March 2015. average daily dose of inhaled corticosteroids was defined as low (1–250 μg), medium (251–500 μg), and high (501–1000 μg) using fluticasone propionate equivalents.

 

Results: We screened 405 COPD patients, of which 48 were dropouts. We identified 58 cataract and 14 glaucoma patients with a prevalence of 16.24% and 3.92%, respectively. We also observed a dose-response relationship with the highest prevalence of cataract (39.6%) and glaucoma (42.8%) at daily doses of 501–1000 μg fluticasone propionate equivalents.

 

Conclusions: It is evident that higher doses and longer duration of inhaled corticosteroid in COPD patients are associated with a higher prevalence of cataract and glaucoma.




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